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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF6
All Species:
38.07
Human Site:
T245
Identified Species:
59.82
UniProt:
P56537
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P56537
NP_002203.1
245
26599
T245
D
S
L
I
D
S
L
T
_
_
_
_
_
_
_
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_534401
245
26551
T245
D
S
L
I
D
S
L
T
_
_
_
_
_
_
_
Cat
Felis silvestris
Mouse
Mus musculus
O55135
245
26492
T245
D
S
L
I
D
S
L
T
_
_
_
_
_
_
_
Rat
Rattus norvegicus
NP_001032429
245
26553
T245
D
S
L
I
D
S
L
T
_
_
_
_
_
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026019
245
26507
A245
D
S
L
I
D
S
L
A
_
_
_
_
_
_
_
Frog
Xenopus laevis
NP_001083080
245
26578
T245
G
S
L
I
D
S
L
T
_
_
_
_
_
_
_
Zebra Danio
Brachydanio rerio
NP_957238
245
26599
T245
D
S
L
I
D
S
L
T
_
_
_
_
_
_
_
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P56538
245
26476
S245
A
A
L
I
E
D
M
S
_
_
_
_
_
_
_
Honey Bee
Apis mellifera
XP_392115
245
26312
S245
A
S
L
I
E
S
M
S
_
_
_
_
_
_
_
Nematode Worm
Caenorhab. elegans
O62106
246
26289
M245
R
D
T
L
I
E
S
M
L
_
_
_
_
_
_
Sea Urchin
Strong. purpuratus
XP_785113
245
26286
T245
D
S
L
V
D
S
L
T
_
_
_
_
_
_
_
Poplar Tree
Populus trichocarpa
XP_002310109
245
26349
V245
N
S
L
I
D
S
Y
V
_
_
_
_
_
_
_
Maize
Zea mays
NP_001148947
245
26554
V245
K
S
L
I
D
S
Y
V
_
_
_
_
_
_
_
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O22290
247
26492
V247
K
S
L
I
D
T
Y
V
_
_
_
_
_
_
_
Baker's Yeast
Sacchar. cerevisiae
Q12522
245
26439
S245
D
T
L
I
E
T
Y
S
_
_
_
_
_
_
_
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
98.3
N.A.
97.9
98.7
N.A.
N.A.
93
92.2
91
N.A.
77.5
81.2
64.2
78.7
Protein Similarity:
100
N.A.
N.A.
99.1
N.A.
99.1
100
N.A.
N.A.
97.5
97.1
95.5
N.A.
89.8
91
80.4
90.6
P-Site Identity:
100
N.A.
N.A.
100
N.A.
100
100
N.A.
N.A.
87.5
87.5
100
N.A.
25
50
0
87.5
P-Site Similarity:
100
N.A.
N.A.
100
N.A.
100
100
N.A.
N.A.
87.5
87.5
100
N.A.
75
87.5
11.1
100
Percent
Protein Identity:
73.8
74.2
N.A.
58.7
72.2
N.A.
Protein Similarity:
84.4
83.6
N.A.
76.9
86.5
N.A.
P-Site Identity:
62.5
62.5
N.A.
50
37.5
N.A.
P-Site Similarity:
75
62.5
N.A.
62.5
87.5
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
7
0
0
0
0
0
7
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
54
7
0
0
74
7
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
20
7
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
87
7
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
14
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
94
7
0
0
54
0
7
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
14
7
0
0
0
0
0
0
0
% M
% Asn:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
80
0
0
0
74
7
20
0
0
0
0
0
0
0
% S
% Thr:
0
7
7
0
0
14
0
47
0
0
0
0
0
0
0
% T
% Val:
0
0
0
7
0
0
0
20
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
27
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
94
100
100
100
100
100
100
% _